Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells

• Ayato Yamada,
• Manabu Abe,
• Yoshinobu Nishimura,
• Shoji Ishizaka,
• Masashi Namba,
• Taku Nakashima,
• Kiyofumi Shimoji and
• Noboru Hattori

Beilstein J. Org. Chem. 2019, 15, 863–873, doi:10.3762/bjoc.15.84

• counterparts (65.8% vs 85.5%). Keywords: caged compound; nitroxide; photolysis; radical; theranostics; two-photon; Introduction Nitroxides (aminoxyl radicals) possess a delocalized unpaired electron and exhibit negligible dimerization reactivity, making them persistent open-shell species [1][2][3][4]. In

Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience

• Serge Pérez and
• Daniele de Sanctis

Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114

• introduces experimental complications as a photo-activable analogue called a caged-compound is required. For this, the substrates have to be modified by adding a photolabile group that prevents the reaction from occurring. The principles of the ideal cage-compound based kinetic crystallography experiment are

A chemist and biologist talk to each other about caged neurotransmitters

• Graham C.R. Ellis-Davies

Beilstein J. Org. Chem. 2013, 9, 64–73, doi:10.3762/bjoc.9.8

• isolation. Thus, to solve the biological problem provided by the biologist (Hess), a newer caging chromophore [18] had to be synthesized by a chemist (Carpenter). Thus, chemists came to play a crucial role in the caged compound field. Chemistry at the service of biology is not unusual or unique, as the

• is thinking about using a caged transmitter in an experiment. I ask the chemist a series of simple questions about the caged compound(s); some of these questions, we discover, do not have simple answers. Glutamate is the most important neurotransmitter in the brain, as its release at nerve synapses

• practical purposes we make stock solutions for freezing in aliquots, and only thaw for use at the desired time. Chemist: Since 1980, the rate of release of the caged compound has been the subject of study by those who develop caged compounds [3]. Since the reaction mechanisms are quite complex, these